Wednesday, May 15, 2013

Health News - Leap in leukemia treatment reported by Dartmouth ...

Lebanon, NH - Doctors at Dartmouth-Hitchcock's Norris Cotton Cancer Center (NCCC) have found a combination of drugs to potentially treat chronic lymphocytic leukemia (CLL) more effectively.

Alan Eastman, the senior researcher on the team and a professor of pharmacology and toxicology at Geisel

Alan Eastman NCCCThe research was published online on May 3, 2013, and it will appear as a letter in the journal Leukemia, a publication of the prestigious Nature Publishing Group. The study helps address a basic problem of treating CLL.

CLL lives both in the blood in circulation, and in lymph nodes and bone marrow. The former is relatively easy to kill, but the disease recurs because of resistant CLL cells in the lymph nodes and bone marrow. The researchers found an innovative drug combination that targets the stubborn CLL cells.

"We have been studying the mechanism in the cancer cells that causes the resistance to treatment," says Alan Eastman, the senior researcher on the team and a professor of pharmacology and toxicology at the Geisel School of Medicine at Dartmouth, "and that in turn, led us to find drugs that target the resistance." Eastman led the team at Dartmouth-Hitchcock's Norris Cotton Cancer Center that also included Ryan Soderquist, Darcy Bates, and Alexey Danilov.?

The researchers found a very effective drug combination of gossypol plus navitoclax to kill CLL cells. "Both drugs have been given to patients, but never in combination, because no one had the mechanistic rationale for doing that. Now we have what we think is the most promising drug combination so far for the treatment of CLL," says Eastman.

CLL cells in the lymph nodes have an increased level of a protein known as BCL-X. Gossypol likely inhibits this protein, which allows the navitoclax to work more effectively to kill the cancer cells. Eastman and his team tested this drug combination on CLL immediately after they came out of the patients.

"The willingness of the patients to participate was integral to this study," Eastman adds. "After 40 years of research, I think this is the most promising idea I have had that might truly impact patient outcome." The researchers hope a clinical trial will soon follow.

This research direction was catalyzed by a?Prouty pilot grant from NCCC and is now supported by a Translational Research Grant from the Leukemia and Lymphoma Society.?

About Norris Cotton Cancer Center at Dartmouth-Hitchcock

Norris Cotton Cancer Center combines advanced cancer research at Dartmouth College and the Geisel School of Medicine at Dartmouth with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center, at Dartmouth-Hitchcock regional locations in Manchester, Nashua, and Keene, NH, and St. Johnsbury, VT, and at 12 partner hospitals throughout New Hampshire and Vermont. It is one of 41 centers nationwide to earn the National Cancer Institute's "Comprehensive Cancer Center"?designation.?Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at cancer.dartmouth.edu.

For more information contact Robin Dutcher at (603) 653-9003.

Source: http://www.healthcanal.com/cancers/38585-leap-in-leukemia-treatment-reported-by-dartmouth-researchers.html

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Beer Hunt: Drinking With Friends Just Got Even More Fun

Just like Untappd, Beer Hunt for iOS combines the best parts of a night out drinking beer with the best parts of Foursquare. The difference here, though, is that Beer Hunt turns all into one colossal social, brew-drinking, liver-killing experience.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/oPJv_XoHP1I/beer-hunt-drinking-with-friends-just-got-even-more-fun-504850080

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Tuesday, May 14, 2013

Brain frontal lobes not sole center of human intelligence

May 13, 2013 ? Human intelligence cannot be explained by the size of the brain's frontal lobes, say researchers.

Research into the comparative size of the frontal lobes in humans and other species has determined that they are not -- as previously thought -- disproportionately enlarged relative to other areas of the brain, according to the most accurate and conclusive study of this area of the brain.

It concludes that the size of our frontal lobes cannot solely account for humans' superior cognitive abilities.

The study by Durham and Reading universities suggests that supposedly more 'primitive' areas, such as the cerebellum, were equally important in the expansion of the human brain. These areas may therefore play unexpectedly important roles in human cognition and its disorders, such as autism and dyslexia, say the researchers.

The study is published in the Proceedings of the National Academy of Sciences (PNAS) today.

The frontal lobes are an area in the brain of mammals located at the front of each cerebral hemisphere, and are thought to be critical for advanced intelligence.

Lead author Professor Robert Barton from the Department of Anthropology at Durham University, said: "Probably the most widespread assumption about how the human brain evolved is that size increase was concentrated in the frontal lobes.

"It has been thought that frontal lobe expansion was particularly crucial to the development of modern human behaviour, thought and language, and that it is our bulging frontal lobes that truly make us human. We show that this is untrue: human frontal lobes are exactly the size expected for a non-human brain scaled up to human size.

"This means that areas traditionally considered to be more primitive were just as important during our evolution. These other areas should now get more attention. In fact there is already some evidence that damage to the cerebellum, for example, is a factor in disorders such as autism and dyslexia."

The scientists argue that many of our high-level abilities are carried out by more extensive brain networks linking many different areas of the brain. They suggest it may be the structure of these extended networks more than the size of any isolated brain region that is critical for cognitive functioning.

Previously, various studies have been conducted to try and establish whether humans' frontal lobes are disproportionately enlarged compared to their size in other primates such as apes and monkeys. They have resulted in a confused picture with use of different methods and measurements leading to inconsistent findings.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/eiG5DM9MW3Y/130513152827.htm

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Bangladesh collapse search over; death toll 1,127

SAVAR, Bangladesh (AP) ? Several major Western brands embraced a safety plan that requires retailers to help pay for factory improvements in Bangladesh, where the three-week search for bodies at the site of the world's worst garment-industry disaster ended Monday with the death toll at 1,127.

The collapse on April 24 of the Rana Plaza factory building focused worldwide attention on the hazardous conditions in Bangladesh's low-cost garment industry and strengthened pressure for reforms.

Bangladesh's government also agreed Monday to allow garment workers to form trade unions without permission from factory owners. That decision came a day after it announced a plan to raise the minimum wage for garment workers. Both moves are seen as a direct response to the collapse of the eight-story building, which housed five clothing factories.

Swedish retailing giant H&M, the largest purchaser of Bangladesh garments, and Britain's Primark Stores announced Monday that they have accepted a legally binding fire and building safety plan drawn up by Bangladeshi and international labor groups. The plan would establish an independent inspectorate to oversee factories, with powers to shut down unsafe facilities and require renovations financed in part by Western retailers.

The Clean Clothes Campaign, which seeks better working conditions in the global garment industry, praised H&M's decision, saying it would pressure other retailers to sign the plan as well.

The agreement was signed earlier by two other companies ? PVH, the owner of the Tommy Hilfiger and Calvin Klein brands, and German retailer Tchibo. Others, however, had refused to sign because the plan was legally binding and costly.

Primark is one of the few retailers that have acknowledged that their clothes were being made by factories in the Rana Plaza building at the time of the collapse.

Working conditions in the $20 billion industry are grim, a result of government corruption, desperation for jobs, and industry indifference. Minimum wages for garment workers are among the lowest in the world at 3,000 takas ($38) a month.

Mohammed Amir Hossain Mazumder, deputy director of fire service and civil defense, said the search for bodies at Rana Plaza was called off at 6 p.m. Monday.

"Now the site will be handed over to police for protection. There will be no more activities from the fire service or army," he said.

Bulldozers and other vehicles have been removed from the building site, which will be fenced with bamboo sticks. Red flags were erected around the site to bar entry.

Reshma Begum, 19, rescued from the rubble of the Rana Plaza building 17 days after the building collapsed, speaks during a media conference at Savar Combined Military Hospital in Savar May 13, 2013. ... more? Reshma Begum, 19, rescued from the rubble of the Rana Plaza building 17 days after the building collapsed, speaks during a media conference at Savar Combined Military Hospital in Savar May 13, 2013. Bangladeshi salvage workers neared on Monday the end of their search for victims of the collapse of a factory building, scouring the basement of the complex that crumbled in on itself killing 1,127 people. REUTERS/Khurshed Rinku (BANGLADESH - Tags: DISASTER SOCIETY TPX IMAGES OF THE DAY) less? The last body was found on Sunday night. A special prayer service will be held Tuesday to honor the dead, said army Brig. Gen. Mohammad Siddiqul Alam Shikder.

For more than 19 days, Rana Plaza in the Dhaka suburb of Savar had been the scene of frantic rescue efforts, anguished families and the overwhelming smell of decaying flesh.

Miracles were few, but on Friday, search teams found Reshma Begum, a seamstress who survived under the rubble for 17 days on cookies and bottled water.

Begum spoke to reporters Monday from the hospital where she is being treated. She told them she never expected to be rescued alive, and she vowed, "I will not work in a garment factory again."

The Rana Plaza owner and eight other people, including garment factory owners, have been detained in the collapse investigation. Authorities say the building owner added floors to the structure illegally and allowed the factories to install heavy equipment that the building was not designed to support.

Bangladesh's Cabinet approved an amendment to the 2006 Labor Act on Monday lifting restrictions on forming trade unions in most industries, government spokesman Mosharraf Hossain Bhuiyan said. The old law required workers to obtain permission before they could unionize.

"No such permission from owners is now needed," Bhuiyan told reporters after the Cabinet meeting presided over by Prime Minister Sheikh Hasina. "The government is doing it for the welfare of the workers."

Local and international trade unions have long campaigned for such changes.

Though the 2006 law technically allowed trade unions ? and they exist in many of Bangladesh's other industries ? owners of garment factories never allowed them, saying they would lead to a lack of discipline among workers.

Trade union leaders responded cautiously.

"The issue is not really about making a new law or amending the old one," said Kalpana Akter of the Bangladesh Center for Workers Solidarity, a group campaigning for garment workers' rights. "In the past whenever workers tried to form associations they were subjected to beatings and harassment," she said. "The owners did not hesitate to fire such workers."

Bangladesh's government has in recent years cracked down on trade unions attempting to organize garment workers. In 2010 Hasina's government launched an Industrial Police force to crush street protests by thousands of workers demanding better pay and working conditions.

That year police arrested at least six activists, including Akter, on charges of instigating workers to vandalize factories. They were later freed, but some charges are still pending.

The activists are also angry that police have made no headway in the investigation of the death of a fellow union organizer, Aminul Islam, who was found dead a day after he disappeared from his home in 2012.

"Islam's case is going nowhere even though police say they are investigating," said Akter.

On Monday, nearly 100 garment factories shut down in the Ashulia industrial area near Dhaka after protests erupted over the death of a female worker whose body was found inside a garment factory.

The body of Parul Akter, 22, was found on Friday. A local police official, Badrul Alam, said she committed suicide.

Thousands of workers took to the streets Monday and vandalized vehicles and shops before police used sticks to disperse the protesters. Several people were injured, said a police official who spoke on condition of anonymity because he was not authorized to speak publicly.

Bangladesh has 5,000 garment factories and 3.6 million garment workers. It is the third-biggest exporter of clothes in the world, after China and Italy. China lacks independent labor unions for all industries; the only legal unions are controlled by the Communist Party, and workers complain that they fail to represent their interests.

On Sunday, the Bangladesh government set up a new minimum wage board that will issue recommendations for pay raises within three months, Textiles Minister Abdul Latif Siddiky said. The Cabinet will then decide whether to accept those proposals.

The wage board will include representatives of factory owners, workers and the government, he said.

Government officials also have promised improvements in safety. Since 2005, at least 1,800 garment workers have been killed in factory fires and building collapses in Bangladesh, according to research by the advocacy group International Labor Rights Forum.

In November, 112 workers were killed in a garment factory in Dhaka. The factory lacked emergency exits, and its owner said only three floors of the eight-story building were legally built.

___

Hossain reported from Dhaka. Associated Press writer Matti Huuhtanen in Stockholm contributed to this report.

Source: http://news.yahoo.com/bangladesh-collapse-search-over-death-toll-1-127-122554495.html

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Farrah Abraham: I'm NOT Kim Kardashian!

Source: http://www.thehollywoodgossip.com/2013/05/farrah-abraham-im-not-kim-kardashian/

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Monday, May 13, 2013

Nano-breakthrough: Solving the case of the herringbone crystal

May 12, 2013 ? Leading nanoscientists created beautiful, tiled patterns with flat nanocrystals, but they were left with a mystery: Why did some sets of crystals arrange themselves in an alternating, herringbone style? To find out, they turned to experts in computer simulation at the University of Michigan and the Massachusetts Institute of Technology.

The result gives nanotechnology researchers a new tool for controlling how objects one-millionth the size of a grain of sand arrange themselves into useful materials -- and a means to discover the rest of the tool chest. A paper on the research is published online May 12 in Nature Chemistry.

"The excitement in this is not in the herringbone pattern, it's about the coupling of experiment and modeling, and how that approach lets us take on a very hard problem," said Christopher Murray, the Richard Perry University Professor and professor of chemistry at the University of Pennsylvania.

Murray's group is well-known for making nanocrystals and arranging them into larger crystal superstructures.

Ultimately, researchers want to modify patches on nanoparticles in different ways to coax them into more complex patterns. The goal is a method that will allow people to imagine what they would like to do and then design a material with the right properties for the job.

"By engineering interactions at the nanoscale, we can begin to assemble target structures of great complexity and functionality on the macroscale," said U-M's Sharon Glotzer, the Stuart W. Churchill Collegiate Professor of Chemical Engineering.

Glotzer introduced the concept of nanoparticle "patchiness" in 2004. Her group uses computer simulations to understand and design the patches.

Recently, Murray's team made patterns with flat nanocrystals made of heavy metals, known to chemists as lanthanides, and fluorine atoms. Lanthanides have valuable properties for solar energy and medical imaging, such as the ability to convert between high- and low-energy light.

They started by breaking down chemicals containing atoms of a lanthanide metal and fluorine in a solution, and the lanthanide and fluorine naturally began to form crystals. Also in the mix were chains of carbon and hydrogen that stuck to the sides of the crystals, stopping their growth at sizes of around 100 nanometers, or 100 millionths of a millimeter, at the largest dimensions. By using lanthanides with different atomic radii, they could control the top and bottom faces of the hexagonal crystals to be anywhere from much longer than the other four sides to non-existent, resulting in a diamond shape.

To form tiled patterns, the team spread a thin layer of nanocrystals and solvent on top of a thick fluid. As the solvent evaporated, the crystals had less space available, and they began to pack together.

The diamond shapes and the very long hexagons lined up as expected, the diamonds forming an Argyle-style grid and the hexagons matching up their longest edges like a foreshortened honeycomb. The hexagons whose sides were all nearly the same length should have formed a similar squashed honeycomb pattern, but instead, they lined up in more complicated, alternating herringbone style.

"Whenever we see something that isn't taking the simplest pattern possible, we have to ask why," Murray said.

They posed the question to Glotzer's team.

"They've been world leaders in understanding how these shapes could work on nanometer scales, and there aren't many groups that can make the crystals we make," Murray said. "It seemed natural to bring these strengths together."

Glotzer and her group built a computer model that could recreate the self-assembly of the same range of shapes that Murray had produced. The simulations showed that if the equilateral hexagons interacted with one another only through their shapes, most of the crystals formed the foreshortened honeycomb pattern -- not the herringbone.

"That's when we said, 'Okay, there must be something else going on. It's not just a packing problem,'" Glotzer said.

Her team, which included U-M graduate student Andres Millan and research scientist Michael Engel, then began playing with interactions between the edges of the particles. They found that that if the edges that formed the points were stickier than the other two sides, the hexagons would naturally arrange in the herringbone pattern.

The teams suspected that the source of the stickiness was those carbon and hydrogen chains -- perhaps they attached to the point edges more easily. Since experimentation doesn't yet offer a way to measure the number of hydrocarbon chains on the sides of such tiny particles, Murray asked Ju Li, now the Battelle Energy Alliance Professor of Nuclear Science and Engineering at the Massachusetts Institute of Technology, to calculate how the chains would attach to the edges at a quantum mechanical level.

Li's group confirmed that because of the way that the different facets cut across the lattice of the metal and fluorine atoms, more hydrocarbon chains could stick to the four edges that led to points than the remaining two sides. As a result, the particles become patchy.

"Our study shows a way forward making very subtle changes in building block architecture and getting a very profound change in the larger self-assembled pattern," Glotzer said. "The goal is to have knobs that you can change just a little and get a big change in structure, and this is one of the first papers that shows a way forward for how to do that."

The paper is titled "Competition of shape and interaction patchiness for self-assembling nanoplates."

Murray is also a professor of materials science and engineering. Glotzer is also a professor of materials science and engineering, macromolecular science and engineering, physics and applied physics. Li is also a professor of material science and engineering.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/kOnNe91VKq0/130512141206.htm

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Ginsburg: Roe gave abortion opponents a target

U.S. Supreme Court Justice Ruth Bader Ginsburg discusses the Roe vs. Wade case on it's 40th anniversary at The University of Chicago Law School in Chicago, Saturday, May 11, 2013. The U.S. Supreme Court decided Roe v. Wade in 1973. It established a nationwide right to abortion. Ginsburg, the second woman to serve as Supreme Court justice, was appointed to the high court by former President Bill Clinton in 1993. (AP Photo/Paul Beaty)

U.S. Supreme Court Justice Ruth Bader Ginsburg discusses the Roe vs. Wade case on it's 40th anniversary at The University of Chicago Law School in Chicago, Saturday, May 11, 2013. The U.S. Supreme Court decided Roe v. Wade in 1973. It established a nationwide right to abortion. Ginsburg, the second woman to serve as Supreme Court justice, was appointed to the high court by former President Bill Clinton in 1993. (AP Photo/Paul Beaty)

U.S. Supreme Court Justice Ruth Bader Ginsburg, right, discusses the Roe vs. Wade case on it's 40th anniversary with University of Chicago Law School Professor Geoffrey Stone, left, at The University of Chicago Law School in Chicago, Saturday, May 11, 2013. (AP Photo/Paul Beaty)

U.S. Supreme Court Justice Ruth Bader Ginsburg, right, discusses the Roe vs. Wade case on it's 40th anniversary with University of Chicago Law School Professor Geoffrey Stone, left, at The University of Chicago Law School in Chicago, Saturday, May 11, 2013. (AP Photo/Paul Beaty)

U.S. Supreme Court Justice Ruth Bader Ginsburg discusses the Roe vs. Wade case on it's 40th anniversary at The University of Chicago Law School in Chicago, Saturday, May 11, 2013. The U.S. Supreme Court decided Roe v. Wade in 1973. It established a nationwide right to abortion. (AP Photo/Paul Beaty)

(AP) ? U.S. Supreme Court Justice Ruth Bader Ginsburg says she supports a woman's right to choose to have an abortion, but feels her predecessors' landmark Roe v. Wade ruling 40 years ago was too sweeping and gave abortion opponents a symbol to target.

Ginsburg, one of the most liberal members of the nation's high court, spoke Saturday at the University of Chicago Law School. Ever since the decision, she said, momentum has been on abortion opponents' side, fueling a state-by-state campaign that has placed more restrictions on abortion.

"That was my concern, that the court had given opponents of access to abortion a target to aim at relentlessly," she told a crowd of students. "... My criticism of Roe is that it seemed to have stopped the momentum that was on the side of change."

The ruling is also a disappointment to a degree, Ginsburg said, because it was not argued in weighty terms of advancing women's rights. Rather, the Roe opinion, written by Justice Harry Blackmun, centered on the right to privacy and asserted that it extended to a woman's decision on whether to end a pregnancy.

Four decades later, abortion is one of the most polarizing issues in American life, and anti-abortion activists have pushed legislation at the state level in an effort to scale back the 1973 decision. This year, governors in North Dakota and Arkansas signed strict new abortion laws, including North Dakota's ban on abortions as early as six weeks into a pregnancy.

Ginsburg would have rather seen the justices make a narrower decision that struck down only the Texas law that brought the matter before the court. That law allowed abortions only to save a mother's life.

A more restrained judgment would have sent a message while allowing momentum to build at a time when a number of states were expanding abortion rights, she said. She added that it might also have denied opponents the argument that abortion rights resulted from an undemocratic process in the decision by "unelected old men."

Ginsburg told the students she prefers what she termed "judicial restraint" and argued that such an approach can be more effective than expansive, aggressive decisions.

"The court can put its stamp of approval on the side of change and let that change develop in the political process," she said.

A similar dynamic is playing out over gay marriage and the speculation over how the Supreme Court might act on that issue.

The court decided in December to take up cases on California's constitutional ban on gay marriage and a federal law that denies to gay Americans who are legally married the favorable tax treatment and a range of health and pension benefits otherwise available to married couples.

Among the questions now is whether the justices will set a nationwide rule that could lead to the overturning of laws in more than three dozen states that currently do not allow same-sex marriage. Even some supporters of gay marriage fear that a broad ruling could put the court ahead of the nation on a hot-button social issue and provoke a backlash similar to the one that has fueled the anti-abortion movement in the years following Roe.

The court could also decide to uphold California's ban ? an outcome that would not affect the District of Columbia and the 11 states that allow gay marriage.

Ginsburg did not address the pending gay marriage cases.

Asked about the continuing challenges to abortion rights, Ginsburg said that in her view Roe's legacy will ultimately hold up.

"It's not going to matter that much," she said. "Take the worst-case scenario ... suppose the decision were overruled; you would have a number of states that will never go back to the way it was."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-12-Ginsburg-Roe%20v%20Wade/id-214cd50bf4b94f9699994cdee23bc28a

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